个人简介 Personal Profile

程斯进，特聘教授、博士生导师。致力于结合前沿的生物信息学方法和单细胞组学技术，通过深入解析肿瘤微环境组成，刻画不同细胞亚群功能特征在分子和细胞层面揭示肿瘤发生免疫逃逸机制，为开发新一代肿瘤免疫治疗靶点提供重要线索。目前研究成果以第一作者或通讯作者发表在Cell (2021, 2025)、Nature Cancer (2024)、Nature Communications (2021)、Genome Biology (2020)、Nucleic Acids Research (2019, 2017)等杂志上。

工作经历

2025 至今    牛博平台基础医学院 特聘教授

2021 至 2025 昌平实验室 研究员

2020 至 2021 中国科学院生物物理研究所 助理研究员/副研究员

教育经历

2018 至 2020 北京大学 博士后

2013 至 2018 北京大学生物信息学专业 博士

2009 至 2013 北京航空航天大学生物工程专业 学士

研究方向 Research Interests

致力于结合前沿的生物信息学方法和单细胞组学技术，通过深入解析肿瘤微环境组成，刻画不同细胞亚群功能特征在分子和细胞层面揭示肿瘤发生免疫逃逸机制，为开发新一代肿瘤免疫治疗靶点提供重要线索

实验室科研项目 Projects

在研科研项目

已结题项目

代表性科研论文 Publications

( *：co-corresponding authors 共同通讯作者; #：co-first authors 共同第一作者)

1.Zedao Liu#, et al., Zhigang Tian*, Yunlang She*, Chang Zou*, Linnan Zhu*, Sijin Cheng*, Yi Zhang*, Wenzhao Zhong*, Chang Chen*, Shugeng Gao*, Zemin Zhang*, A single-cell atlas reveals immune heterogeneity in anti-PD1-treated non-small cell lung cancer, Cell, 2025, 188:1-16.

2. Xiaojing Chu#, Xiangjie Li#, Yu Zhang#, Guohui Dang, Yuhui Miao, Wenbin Xu, Jinyu Wang, Zemin Zhang*, Sijin Cheng*. Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms. Nat Cancer, 2024. 5, 1409–1426.

3. Xiaojing Chu#, Yu Zhang#, Sijin Cheng*. Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics. Chin J Cancer Res, 2022. 34(6): 543-553.

4. Sijin Cheng#, Ziyi Li#, Ranran Gao, Baocai Xing, Yunong Gao, Yu Yang, Shishang Qin, Lei Zhang, Hanqiang Ouyang, Peng Du, Liang Jiang, Bin Zhang, Yue Yang, Xiliang Wang, Xianwen Ren, Jinxin Bei, Xueda Hu, Zhaode Bu*, Jiafu Ji*, Zemin Zhang*. A Pan-Cancer Single-Cell Transcriptional Atlas of Tumor Infiltrating Myeloid Cells. Cell, 2021.184(3): p. 792-809 e23.

5. Qianqian Zhang#, Sijin Cheng#, Yongzhi Wang#, Mengdi Wang#, Yufeng Lu, Zengqi Wen, Yuxin Ge, Qiang Ma, Youqiao Chen, Yaowu Zhang, Ren Cao, Min Li, Weihao Liu, Bo Wang, Qian Wu*, Wenqing Jia*, Xiaoqun Wang*. Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages. Nat Commun, 2021.12, 6867.

6. Ming O.Li, Natalie Wolf, David H. Raulet, Leila Akkari, Mikael J. Pittet, Paulo C. Rodriguez, Rosandra N. Kaplan, Ariel Munitz, Zemin Zhang, Sijin Cheng, Nina, Bhardwaj. Innate immune cells in the tumor microenvironment. Cancer Cell, 2021, 39(6), p725-729. (Voices)

7. Rui Yang#, Sijin Cheng#, Nan Luo#, Ranran Gao, Kezhuo Yu, Boxi Kang, Li Wang, Qiming Zhang, Qiao Fang, Lei Zhang, Chen Li, Aibin He, Xueda Hu, Jirun Peng*, Xianwen Ren* and Zemin Zhang*. Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis. Genome Biol, 2020. 21(1).

8. Shuai Jiang#, Sijin Cheng#, Li-Chen Ren, Qian Wang, Yu-Jian Kang, Yang Ding, Mei Hou, Xiao-Xu Yang, Yuan Lin, Nan Liang, Ge Gao*. An expanded landscape of human long noncoding RNA. Nucleic Acids Res, 2019, 47, 7842-7856.

9. Sijin Cheng, Shuai Jiang, Fang-Yuan Shi, Yang Ding, and Ge Gao*, Systematic identification and annotation of multiple-variant compound effects at transcription factor binding sites in human genome. Journal of Genetics and Genomics, 2018, 45, 373-379.

10. Linna Peng#, Sijin Cheng#, Yuan Lin#, Qionghua Cui, Yingying Luo, Jiahui Chu, Mingming Shao, Wenyi Fan, Yamei Chen, Ai Lin, Yiyi Xi, Yanxia Sun, Lei Zhang, Chao Zhang, Wen Tan, Ge Gao*, Chen Wu*, Dongxin Lin*. CCGD--ESCC: a comprehensive database for genetic variants associated with esophageal squamous cell carcinoma in Chinese population. Genomics Proteomics Bioinformatics, 2018, 16, 262-268.

11. Sijin Cheng, Fang-Yuan Shi, Huan Liu, Yang Ding, Shuai Jiang, Nan Liang, Ge Gao*. Accurately annotate compound effects of genetic variants using a context-sensitive framework. Nucleic Acids Res, 2017, 45, e82.